Based on a large series of subsequent studies of the groups of Robert S. Fujinami, H. Steve White, and Karen S. Wilcox at the University of Utah, which were reviewed by Libbey and Fujinami (2011) and DePaula-Silva et al. (2017, 2021), it was suggested that infiltrating monocytes (CD45hi CD11b+) present in the brain of B6 mice at day 3 post-infection are an important source of IL-6, which critically contributes to the development of acute seizures in the TMEV-induced seizure model. Here, IL6 is linked to infection.