The involvement of CD8+ cytotoxic T lymphocytes and viral clearance in the development of acute seizures in the TMEV-induced seizure model was assessed through the use of OT-I transgenic mice (B6 background), in which the majority of the CD8+ T cells carry an ovalbumin-specific T-cell receptor (Kirkman et al., 2010). Here, CD8A is linked to Seizure.