The authors mentioned that CB1 receptor activation can antagonize the effect of dopamine receptor agonists on the one hand, yet may also act as a downstream effector of D2 receptors, on the other hand (Wang et al., 2022), which makes the expected clinical outcome unclear regarding the possible activation or inhibition of CB1 on PD symptoms, as well as on the response and side effects of dopamine agonists in patients with PD receiving cannabinoids as medication. The gene discussed is CNR1; the disease is Parkinson disease.