The APP Swe corresponds to genetic mutation, which involves a substitution of two amino acids, from lysine (K) and methionine (M) to asparagine (N) and leucine (L), at a point immediately adjacent to the β-secretase site in APP in rare familial AD cases with six times increased Aβ production (Citron et al., 1992; Haass et al., 1995). Here, APP is linked to Alzheimer disease.