ADAM10 and Alzheimer disease: Based on the significant abolition of sAPPα generation in mice with neural ADAM10 conditionally knocked out (Jorissen et al., 2010) and strong correlation between reduced ADAM10 and decreased sAPPα in the platelets and cerebrospinal fluid of sporadic AD patients (Colciaghi et al., 2002), ADAM10 was strongly suggested as the constitutive α-secretase that is active at the cell surface.