P. aculeata Mill petroleum ether site regulate the p38/MAPK pathway by inhibiting the expression levels of p-p38 and p-MK2 and reduce the phosphorylation of TTP, and further inhibit the secretion of NO, TNF-α, IL-6, and PGE2 inflammatory cytokines, eventually slow down the inflammatory response and the progression of RA disease (Figure 10). This evidence concerns the gene IL6 and rheumatoid arthritis.