CKLF and keloid: In addition, pro-inflammatory factors such as interleukin (IL)-1α, IL-1β, and IL-8, CKLF-1, and COX-1 are upregulated in the keloid tissue, suggesting that in patients with keloids, pro-inflammatory genes in the skin are sensitive to trauma, which in turn may promote chronic inflammation and lead to excessive keloid growth (Abdou et al., 2014; Lin et al., 2020; Wu et al., 2020).