TGFB1 and keloid: Here we begin with an introduction to the various factors involved in the progression of keloid pathology and then describe the recent advances in biomechanical regulation of keloids as accumulated evidence suggests that several mechanotransduction signaling pathways, such as TGF-β/Smad signaling pathway, Integrin signaling pathway, YAP/TAZ signaling pathway, and calcium ion pathway, are involved in the process of keloid fibrosis, and have been proved to play an important role in keloid development.