Downregulation of the YTHDC2 gene can significantly inhibit the translation of tumor metastasis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1α), and the high expression of this molecule is positively correlated with tumor stage and colon cancer metastasis (Tanabe et al., 2016). Here, HIF1A is linked to malignant colon neoplasm.