METTL3 and colorectal cancer: Shen et al. found that the m6A methyltransferase METTL3 regulates the expression levels of HK2 and SLC2A1 by regulating m6A expression and stabilizing m6A under the action of the methyl-binding protein IGF2BP, which further promotes the activation of the glycolytic pathway, inducing malignant proliferation of colorectal cancer cells (Shen et al., 2020).