WDR4 and acute myeloid leukemia: Orellana et al. established a link between higher METTL1/WDR4 complex expression and elevated m7G tRNA levels and malignancy and poor survival in a variety of human malignancies, including glioblastomas, breast tumors, and acute myelogenous leukemias, among others (33), m7G methylation can selectively boost the translation of specific cell cycle regulating and carcinogenic mRNAs that are enriched in corresponding m7G-tRNA cognate codons, thereby buffering against ribosome stopping, which can result in translation inhibition via ribosome collisions (34).