TP53 and colorectal adenocarcinoma: In addition, Saller et al. reported CYFIP2 as a candidate p53 target gene in H1299 lung cancer cells (46), and Jackson et al. verified in DLD1 colorectal adenocarcinoma cells that CYFIP2 can act as a p53-inducible gene to promote apoptosis in colorectal adenocarcinoma cells (47).