Animal experiments found that the combination of ARS and HCQ can reduce the levels of 24-h urine protein, IgA, and IgG immune complex deposition in the glomerulus through NF-κB/NLRP3 signaling [22] and improve the barrier function of the glomerular filtration membrane by regulating the immune response in IgA nephropathy rats [32]. This evidence concerns the gene NFKB1 and IgA glomerulonephritis.