IGHA1 and IgA glomerulonephritis: The pathogenesis of IgA nephropathy is related to a “multi-hit” autoimmune process [5], which involves increased production of atypical galactose-deficient mucosal-type IgA1 antibodies, with the formation of anti-IgA1 autoantibodies, deposition of IgA1-containing immune complexes within the glomerular mesangium, and incitement of a nephritogenic inflammatory response by these immune complexes.