CADRO categories include amyloid beta; tau; apolipoprotein E (ApoE), lipids and lipoprotein receptors; neurotransmitter receptors; neurogenesis; inflammation; oxidative stress; cell death; proteostasis/proteinopathies; metabolism and bioenergetics; vasculature; growth factors and hormones; synaptic plasticity/neuroprotection; gut-brain axis; circadian rhythm; environmental factors; epigenetic regulators; multi-target; unknown target; and others. Here, APOE is linked to proteostasis deficiencies.