All these PPARα-target genes tended to be lower in the HET mice, whereas Cyp4a14 was markedly induced (↑213 fold) and MCAD tended to be induced (↑1.5 fold, p = 0.056) in the KO mice (Fig. 5E). The gene discussed is PPARA; the disease is medium chain acyl-CoA dehydrogenase deficiency.