Autophagy is regulated by nutritional status and intracellular stress, which are altered under diabetic conditions, and corresponding alterations in Sirtuin type-1 (Sirt1), Adenosine 5'-monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) autophagy pathways potentially exacerbate organelle dysfunction and lead to DN [7]. This evidence concerns the gene MTOR and liver dysplastic nodule.