PGM1 and neoplasm: However, PGM1 showed the opposite effect in lung cancer, under glucose depletion conditions, where researchers found that an upregulation of PGM1 increased glycogen content, and thereby reduced the rates of glycogen decomposition and glycogenesis, glycogen accumulation induces cell survival and proliferation under conditions of glucose depletion, decrease in PGM1 reduces tumor cell proliferation under prolonged glucose depletion [16].