In the respiratory system, TP73-AS1 promotes tumor growth and cell cycle progression of NSCLC via a pathway involving TP73-AS1/miR-449a/EZH2 or through the regulation of miR-21 which controls the progression of lung adenocarcinoma through the PI3K/AKT axis [21–23]. This evidence concerns the gene EZH2 and lung adenocarcinoma.