In gastric cancer, the downregulation of TP73-AS1 suppressed cell proliferation, invasion and migration via miR-194-5p/SDAD1, HMGB1/RAGE, WNT/β catenin or EMT/Bcl-2/caspase-3 signaling pathways but Liu et al. found that miR-223-5p may target TP73-AS1 to promote the invasion and migration of gastric cancer patients [11–14, 30]. Here, HMGB1 is linked to gastric cancer.