IRS1 and neoplasm: Among them, fifteen were highly expressed in tumor tissues (TRIB3, ERN1, IRS1, CXCL2, TLR4, ITPR2, BCL2L11, TP53, CCL2, HMOX1, PDIA5, CXCR4, CYBB, HCP5, CASP8), and one was highly expressed in normal tissues (PDIA2) (Fig. 1B and Table 1).