Other genes found to be significantly upregulated in the F2 cells included a diverse geneset composed of G0/G1 Switch 2 (G0S2 )[39], COL7A 1[40], interleukin 16 (IL-16) [41], and delta/notch-like epidermal growth factor-related receptor (DNER) [42], all of which have been previously reported to enhance breast cancer metastases. The gene discussed is IL16; the disease is breast cancer.