However, after adjustment for age, ECOG PS, BMI, smoking status, PD-L1 status, and GS, multivariate analyses revealed that good PS (PS ≤ 1), high PD-L1 expression, and emphysema (GS ≥ 1) were independently associated with better OS, whereas smoking status was not. The gene discussed is CD274; the disease is pulmonary emphysema.