Figure 6a–i shows the top 9 immune-associated signaling pathways, including the CTLA4 pathway, antigen presentation folding assembly and peptide loading of class I MHC, autoimmune thyroid disease, inflammatory pathway, antigen processing and presentation, IL5 pathway, cytokines and inflammatory response, TCR signaling, and TH1TH2 pathway. This evidence concerns the gene CTLA4 and autoimmune thyroid disease.