FOXP3 expression showed a statistically significant correlation with infiltration of B cells, CD4+ T cells, CD4+ T cells, neutrophils, macrophages and dendritic cells and predicted the breast cancer cellsʼ s response to anticancer drugs, the main 50 genes were involved in FOXPs, our study suggested that FOXPs could serve as a biomarker for tumor detection, therapeutic design and prognosis. Here, CD4 is linked to breast cancer.