TNFRSF10B and head and neck carcinoma: Apigenin has previously been shown to target the extrinsic pathway of apoptosis when used in combination with: (1) TRAIL in Jurkat cells via upregulation of the expression of the DR5 gene70; and (2) 5-fluorouracil and cisplatin in head and neck carcinoma cells (SCC25 and A431) via upregulation of the expression of TNFR and TRAILR genes58.