TNFRSF1A and acute myeloid leukemia: In THP-1 acute myeloid leukaemia cells, there was a significant decrease in the expression of BCL2, BCLX, and BAD genes and proteins; with a significant increase in TNFR1/TNFRSF1A, CASP-9, and CASP-3 gene expression, when compared to the vehicle control (P ≤ 0.05) (Table 1).