Likewise, Chen et al., 2019 showed that apigenin could inhibit tumorigenesis and induce apoptosis in cisplatin-resistant colon cancer cells (HT-295), when grown in vitro and in vivo as mouse xenografts, through the upregulation of pro-apoptotic BAX and downregulation of anti-apoptotic BCL271. This evidence concerns the gene BAX and malignant colon neoplasm.