Similarly, three previous studies found that apigenin could synergistically increase caspase 9 gene expression, when used in combination with: (1) TRAIL for 24 h in Jurkat acute lymphoblastic leukaemia cells70, (2) Abivertinib for 24 h in U2932 and OVI-LY1 diffuse large B-cell lymphoma cells; via the downregulation of PI3K/mTOR62; and (3) Cisplatin in A549 lung cancer cells61. Here, CASP9 is linked to lung cancer.