Death receptor related genes and proteins were shown to be increased in this study by apigenin, however these failed to demonstrate synergistic responses when combined with chemotherapy agents, with the only synergistic increases seen in TNFR1/TNFRSF1A in THP-1 myeloid leukaemia cells, when treated with apigenin and etoposide (Fig. 8); and in TRAILR1/DR4 in Jurkat lymphoid leukaemia cells when treated with apigenin and cyclophosphamide (Fig. 9). This evidence concerns the gene TNFRSF1A and lymphoid leukemia.