CASP8 and myeloid leukemia: This is supported by our previous work, which demonstrated apigenin could synergistically enhance the action of topoisomerase inhibitor agents (e.g., etoposide), and alkylating agents (e.g., cyclophosphamide) reducing ATP levels, and inducing apoptosis (caspase 8, 9 and 3 induction and morphological evidence of apoptosis) in both lymphoid and myeloid leukaemia cell lines; whilst protecting normal hematopoietic stem cells (CD133+HSC and CD34+HSC)63,64.