CASP8 and myeloid leukemia: In THP-1 myeloid leukaemia cells, the use of the LSD for apigenin of 10 μM, caused a significant increase of pro-apoptosis-related genes and proteins (BAD, BAX, CYT c, HTRA2/OMI, SMAC/DIABLO, TRAILR1/DR4, TNFR1/TNFRSF1A, FAS/CD95, FADD, CASP-8, CASP-9 and CASP-3), when compared to the vehicle control (P ≤ 0.05).