AKT1 and diffuse large B-cell lymphoma: In a recent study by Huang et al., 2020, they demonstrated apigenin synergistically enhanced the action of the BTK inhibitor abivertinib, and this action was associated with an apigenin-mediated downregulation of BCLX by the suppression of the PI3K/p-AKT pathway in diffuse large B-cell lymphoma cell lines (U2932 and OCI-LY10) at 24 h62.