Previously, we showed that MED26 plays an important role in the recruitment of LEC–Cap-binding complex (CBC)–NELF to RDH genes and then helps to recruit 3′-end processing factors, including HCC or Integrator to the RDH or snRNA genes, respectively, leading to appropriate 3′-end processing22. The gene discussed is SDR9C7; the disease is hepatocellular carcinoma.