Cytosolic branched-chain aminotransferase (BCAT1) has been identified as a genomic biomarker for cardiotoxicity studies; it is also down-regulated in acute myocardial infarction and experimentally heart-specific upregulation of BCAT1 is protective against ischemic myocardial injury45,46. The gene discussed is BCAT1; the disease is myocardial infarction.