In tumor genomes, AKT2 alterations significantly co-occur with ARID1A alterations (OR = 2.0, FDR<0.1% in MSK-IMPACT cohort of 10,945 samples;52 replicated at OR = 1.4, FDR<0.1% in an independent TCGA pan-cancer cohort of 10,967 samples; analysis via cBioPortal53). This evidence concerns the gene AKT2 and cancer.