It is reported that tumor-educated fibroblasts would serve to construct a tumor-supportive host stroma via STAT3 signaling17 and JNK signaling18 pathways, promoting ECM degradation and reconstruction, inducing angiogenic and pro-inflammatory response of endothelial cells, recruiting VLA-4+ bone marrow-derived cells by localized FN deposition for niche formation19. Here, STAT3 is linked to neoplasm.