To evaluate prevention of peptide administration on developing PMN immunosuppressive environment, protein level of TGF-β in PMN (Fig. 5c), the well-known immuno-modulator produced by MDSC to regulate the establishment of immunosuppressive tumor-supportive niche, as well as the pro-inflammatory cytokine IL-6 was detected (Fig. 5d). This evidence concerns the gene IL6 and neoplasm.