In future studies, the use of another AD mouse model could give more insights into age effects, e.g. APP/PSEN starts to aggregate amyloid-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β protein at 5–6 months in their brains, allowing the broadest range of time window. Here, APP is linked to Alzheimer disease.