CDK4 and neoplasm: Similar to the in vitro data, the WB analysis of the tumor tissue excised from DU145 xenograft mouse also indicated that the cell proliferation and apoptosis-related proteins p-4E-BP1, p-RB, CDK4/6, RRS1, and XIAP were deregulated, and P27, P53, CCNG2, and cleaved PARP were upregulated (Fig. 7g).