Previous reports mainly considered DYRK2 as a cancer suppressor, which induces apoptosis through promoting phosphorylation of P53 in colorectal cancer65, inhibits cell cycle from G1 to S phase via degrading c-JUN and c-MYC in breast cancer22, and suppresses EMT by accelerating SNAIL degradation in glioma66. The gene discussed is JUN; the disease is cancer.