Data obtained using this versatile in vivo system showcases breadth of proteomic labeling in neurons and astrocytes, regional Camk2a neuronal and astrocyte proteomic signatures, and neuron and astrocyte-specific phospho-protein signaling (MAPK and Akt/mTOR) and cytokine signatures with relevance to several neurological disorders. The gene discussed is CAMK2A; the disease is nervous system disorder.