Cortex and hippocampal Camk2a neuron proteins enriched in glutamatergic transmission proteins and long-term potentiation (e.g., Lingo1, Homer1, Gria1) were associated with mental health disorders (schizophrenia, bipolar disease, depression, autism), neurodevelopmental disorders, essential tremor, and primary epileptic disorders (e.g., West syndrome). This evidence concerns the gene GRIA1 and major depressive disorder.