Grin2a is also known to interact directly and indirectly with Dlg4 (PSD-95), which regulates glutamate NMDA and α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA) receptor trafficking at the synapse45 with significant roles in Alzheimer’s disease (AD) biology46. Here, DLG4 is linked to Alzheimer disease.