C5AR1 and neuropathy: In vivo, the significant reduction of paclitaxel-induced allodynia that we observed in C5aR1 knock-out mice and after treatment with a C5aR1 inhibitor upon paclitaxel administration demonstrated that C5aR1 is crucially involved in the mediation of paclitaxel neuropathy and suggested the potential therapeutic effects of the inhibition of C5aR1 to treat or prevent this condition.