Here, we demonstrate that while CMV-seronegative donor Vγ9negVδ2 T cells lacked T-bet, HOBIT and BLIMP-1, these markers were markedly upregulated upon CMV infection and seroconversion post-transplantation, alongside transition from CD27hi to CD27lo/neg status, suggesting transition to the Teffector transcriptional program (Figure 6B); in contrast, Vγ9+Vδ2+ T cells were strongly granzyme A/B+, T-bet+ and Eomes+ before and after CMV infection and seroconversion (Figure S6A). This evidence concerns the gene GZMA and cytomegalovirus infection.