However, on a genetic basis, there is no overlap between the risk genes of AMD (e.g., CFH, C2, C3, CETP, VEGFA, APOE)37,57 and the genes that have an influence on advanced shortening of the telomeres (e.g., TERT, TERC, TRF1, NAF1, RTEL).30 The gene discussed is C2; the disease is age-related macular degeneration.