As shown in Fig. 3, among the cytokines secreted by tumors, GM‐CSF and G‐CSF could not only promote the myeloid‐biased differentiation, but also induce the differentiation of myeloid precursors into functional TAMs, TANs, or MDSCs [99, 100], and these cell types could negatively regulate immune responses and facilitate tumor metastasis and angiogenesis [60, 101]. This evidence concerns the gene CSF3 and neoplasm.