CSF2 and metastatic melanoma: For example, patients with stage IV metastatic melanoma injected with heat shock protein peptide complex gp96 (HSPPC‐96), GM‐CSF (75 μg subcutaneously into the vaccine site) once a week for 4 weeks, and then once every 2 weeks, could promote the production of new subsets of myeloid suppressor cells (MSCs) [54].