There was evidence that in a murine H22 subcutaneous hepatoma model, spleen weight was identified to be positively correlated with tumor weight, and the proportion of CD8+ T lymphocyte in the spleen were decreased, while the percentages of M‐MDSCs, CD11b+ F4/80+ macrophages and PMN‐MDSCs at day 21 after tumor cell inoculation [168]. Here, ITGAM is linked to neoplasm.