SIRT1 and neoplasm: Of these, miR‐30e or miR‐30e‐5p exerts its tumor suppressor function by targeting specific genes such as IRS1 in breast cancer [57], HOXA1 in lung carcinomas [58], ITGA6 and ITGB1 in colorectal cancer [59], MTDH (Metadherin) in bladder cancer [60] and USP22/Sirt1/JAK/STAT3 signaling pathway in nonsmall cell lung cancer [61].