Moreover, we analyzed the PPL expression profile in pan-cancer, we could clearly saw that the PPL possessed higher expression trend in tumor like OV, PAAD (pancreatic), STAD (stomach adenocarcinoma), and possessed lower expression trend in tumor like ACC (adrenocortical carcinoma) and ESCA (esophageal carcinoma) (Fig. 1c), which indicated the different roles of PPL in pan-cancer. Here, PPL is linked to carcinoma of esophagus.