NOTCH2 and neoplasm: Moreover, for potential translational relevance, we treated mice bearing established COR-L279 tumors with GO-203 and found inhibition of tumor growth in association with downregulation of MUC1-C, MYC, NOTCH2, and NEUROD1 (Fig. 6F and G), indicating that the MUC1-C→MYC→NOTCH2 pathway is necessary for conferring SCLC tumorigenicity.