NOTCH2 and small cell lung carcinoma: In concert with the demonstration that MUC1-C is necessary for activation of MYC target genes in COR-L279 and H526 cells, silencing MUC1-C in these models also resulted in suppression of NOTCH2 transcripts (Fig. 3G, left and right), in support of a MUC1-C→MYC→NOTCH2 pathway pathway in NE and non-NE SCLC cells.