In extending involvement of the MUC1-C→MYC→NOTCH2 pathway in SCLC dedifferentiation, we found that silencing MUC1-C in H69 (Fig. 5A, left and right) and DMS53 (Fig. 5B, left and right) cells suppresses self-renewal capacity as assessed by decreases in tumorsphere formation. The gene discussed is MUC1; the disease is small cell lung carcinoma.