These results were corroborated by the clinical data, showing elevation of both chymase and tryptase in SFTS patients, which were increased to an even higher level in those presenting vascular leakage and bleeding, moreover, evidenced by dysregulation of adhesion molecules that were indicative of endothelial dysfunction observed in those with higher chymase and tryptase release. The gene discussed is CMA1; the disease is endothelial dysfunction.