In addition glioblastoma, IL13Rα2 blocks the normal apoptosis pathway through signal transducer and activator of transcription (STAT)-6 triggered by IL-13/IL-4 and induces STAT-3 up regulation in glioma (Ou et al., 2021; Vázquez Cervantes et al., 2021). Here, IL13RA2 is linked to central nervous system cancer.