For example, tubulointerstitial nephritis antigen‐like 1 (Tinagl1) which has been found to suppress tumorigenesis and metastasis in triple‐negative breast cancer,[28] and cystatin‐M (Cst6) a cysteine protease inhibitor that is epigenetically silenced during breast cancer progression and whose activity is associated with suppression of tumor malignancy.[29]. This evidence concerns the gene TINAGL1 and breast carcinoma.