IFNA1 and cancer: Activation of the IFN/STAT1 pathway in cancer cells as a result of treatments showed a positive correlation with response to chemotherapy.[26] However, BST‐2 also appears to have opposing functions where its high expression is correlated with breast tumor aggressiveness, cancer cell survival, and metastasis.[27] Finally, some of the other upregulated signatures identified in responders were also found to have an antitumorigenic association (Table 2).