Finally, we isolated the CD15+ cells and CD4/CD8pos T cells at 24 h from APCCs and analyzed the expression of key immune‐suppressive genes of MDSCs (ARG1, NCF1, NCF4, CYBB) which mediate MDSC arginase 1 secretion and NO generation to inhibit T cells within the tumor TME. This evidence concerns the gene CD4 and neoplasm.