Numerous studies have shown that dysregulation of the VEGF‐independent pro‐angiogenic factor Insulin Growth Factor 1 (Igf1) is associated with pathological NV in proliferative diabetic retinopathy or retinopathy of prematurity (Boulton et al., 1997; Haurigot et al., 2009; Hellstrom et al., 2001; Kondo et al., 2003; Meyer‐Schwickerath et al., 1993; Ruberte et al., 2004; Smith et al., 1999; Wilkinson‐Berka et al., 2006). The gene discussed is IGF1; the disease is proliferative diabetic retinopathy.