Numerous studies have shown that Igf1 is associated with pathological NV in proliferative diabetic retinopathy or retinopathy of prematurity (Boulton et al., 1997; Haurigot et al., 2009; Hellstrom et al., 2001; Kondo et al., 2003; Meyer‐Schwickerath et al., 1993; Ruberte et al., 2004; Smith et al., 1999; Wilkinson‐Berka et al., 2006). This evidence concerns the gene IGF1 and retinopathy of prematurity.