Among various p97 cofactors, our attention was caught from Nploc4 adaptor for a number of reasons: (i) it was the most induced in TA muscle both in cancer cachexia and in ALS (Figures5 and S6); (ii) the increase in gene expression was also confirmed by a raise in the protein content of Nploc4 in the atrophied muscles (Figures6, S8, S9, and S10); and (iii) its induction exceeded that of p97 in atrophied muscles (ALS/cancer cachexia) (Figures1, 2, 5, and 6). Here, NPLOC4 is linked to amyotrophic lateral sclerosis.