Significant correlations were found between RASSF4 low expression status and advanced TNM stage (p = 0.0076), high T status (p = 0.0036), nodal metastasis (p = 0.0076) and high Ki‐67 index (p = 0.0031) (Table 2), suggesting RASSF4 downregulation serve as an indicator of malignant feature of CRC. The gene discussed is RASSF4; the disease is colorectal carcinoma.