TBL1XR1 and infantile spasms: In addition, there was a second case reporting an individual with West syndrome who had a de novo p.Gly29Asp (NM_024665.4:c.86 G > A) variant in the N‐terminal LisH domain of TBL1XR1 (Muir et al., 2019).The LisH domain is required for oligomerization, transcriptional repression, and binding to hypoacetylated H2B and H4 (Yoon et al., 2005).