KDM3A and Intervertebral disk degeneration: Furthermore, transfection of miR-155-3p mimic into intervertebral disc degeneration (IDD) model cells showed attenuation of the IDD phenotype, promoting proliferation and inhibiting apoptosis, while increasing autophagy rate with lysine demethylase 3A (KDM3A), identified as a potential causative target of the miRNA (figure 7) [111].