The heatmap showed that the HMGA1-high cluster expressed TMSB10 (Zhang et al., 2017), CTSD (Ashraf et al., 2019) and LGALS1 (Balestrieri et al., 2021; Jung et al., 2007), which are correlated with poor prognosis in breast cancer. The gene discussed is HMGA1; the disease is breast cancer.