MAPT and Atrophy: In this same cohort, previous analysis using the T1-weighted images suggested limited areas of atrophy in subjects with a higher CAIDE.40 In the past, it has been shown that entropy and contrast of T1 images relate to tau burden in the neocortex.41 A further analysis with cardiovascular risk factors, age and sex as predictors unveiled that females had a different textural profile compared with males in both WMH (more heterogeneous textural profile) and NAWM (less heterogeneous), with ageing mainly related to textural alterations in NAWM (more heterogeneous).