The results of the current study demonstrate that VPA plays its role through the upregulation of SOCS-1, SOCS-2, SOCS-3, SOCS-5, SOCS6, and SOCS-7 genes, resulting in cell growth inhibition and apoptosis induction in colon carcinoma IS1, IS2, and IS3 cell lines. Here, SOCS1 is linked to colon carcinoma.