The current study aimed to investigate the effect of valproic acid (VPA) on SOCS-1, SOCS-2, SOCS-3, SOCS-5, SOCS6, and SOCS-7 gene expression and cell growth inhibition in colon carcinoma IS1, IS2, and IS3 cell lines to determine whether valproic acid can reactivate the expression of the mentioned genes in the named cell lines. The gene discussed is SOCS1; the disease is colon carcinoma.