The results of our study showed that the sensitivity of AFP in the gastric cancer group was only 16.04%, and AFP positive levels in the M1 stage were statistically significant compared with those in the M0 stage and control group (P < 0.001), although the positive of AFP (P = 0.045) was not statistically significant when comparing the M0 stage with the control group. The gene discussed is AFP; the disease is gastric cancer.