For the cirReNET we built, there were many targeted genes involved in the mechanism of tumor genesis, such as AKT1 (Liu et al., 2020), ErbB2 (Li et al., 2018a), ITGB7 (Sun et al., 2020), BAX, MAPK, FBXL12 (Nita et al., 2016), CCL7 (Zhang et al., 2020b) and so on. This evidence concerns the gene AKT1 and neoplasm.