And the 150 hub genes in the downregulated circRNA-upregulated miRNA-downregulated mRNA (DcUiDm-RNA) network, 10 hub genes (RNF217, KLHL5, UNKL, PTGER3, FBXO32, TRIM9, KCTD7, KLHL42, SRSF11, RBM5)were lower expression in the CRC group in the DcUiDm-RNA network. Here, KLHL5 is linked to colorectal carcinoma.