Ma & Deng (2021) confirmed that miR-665 plays a role in inhibiting the proliferation, migration and invasion of CRC cells. MiR-448 (Zhang et al., 2019) has also been confirmed to play a tumor suppressive role by promoting cell apoptosis. Similarly, for circRNA with low expression in CRC, such as hsa_circRNA_071106, its predicted miRNAs should play a carcinogenic role. It has been reported that overexpression of miR-29a-5p (Wang et al., 2020) in colorectal cancer cells can amplify inflammatory effects and promote CRC progression through the STAT3 signaling pathway. Here, STAT3 is linked to colorectal carcinoma.