APLN and colorectal carcinoma: We chose the top 50 hub genes to enter into GEPIA to screen (Fig. 9 and Fig. S4), and the 150 hub genes in the upregulated circRNA-downregulated miRNA-upregulated mRNA (UcDiUm-RNA) network, there was higher expression for 12 hub genes (CCL4, APLN, FBXO22, SH3KBP1, CKAP4, PDIA6, RCN1, TP53, CCND1, EZH2, E2F2, CASP3) in the CRC group as compared to normal tissues group.