For the cirReNET we built, there were many targeted genes involved in the mechanism of tumor genesis, such as AKT1 (Liu et al., 2020), ErbB2 (Li et al., 2018a), ITGB7 (Sun et al., 2020), BAX, MAPK, FBXL12 (Nita et al., 2016), CCL7 (Zhang et al., 2020b) and so on. Here, ERBB2 is linked to neoplasm.