Especially BARI may block the viral entry into the cells by inhibiting the members of the numb-associated kinase (NAK) family, such as adaptor associated protein-kinase-1 (AAKI) and cyclin-G associated kinase (GAK), which are involved in the viral endocytosis.47 Currently, both drugs are used to treat RA and other inflammatory arthritides in a dose of 5mg twice daily for TOFA and 2mg twice daily for BARI. The gene discussed is GAK; the disease is rheumatoid arthritis.