As tumor cells and trophoblasts exhibit many similarities and we observed miR-135a-5p overexpression to inhibit PTPN1 expression within HTR-8/SVneo, we hypothesize that miR-135a-5p may impair proliferative, invasive, and migratory activity of trophoblasts via PTPN1. This evidence concerns the gene PTPN1 and neoplasm.