However, in the LPS-induced model of depression, activation of the 5-HT2C receptor (F(3,15) = 1.680, P > 0.05) as coupled with Gαi-2 (F(3,15) = 6.931, P < 0.01) mediated the decreases in downstream cAMP (F(3,15) = 14.31, P < 0.001, Fig. 2D) and PKA (F(3,15) = 8.419, P < 0.01) expression and increased ASK1 (F(3,15) = 9.437, P < 0.001). Here, MAP3K5 is linked to depressive disorder.